David Dolphin, Christian Bruckner
Methods to Prepare B,B'-Dihydroxy Meso-Substituted Chlorins, Isobacteriochlorins and Bacteriochlorins
Title compounds were prepared by osmylating a β,β'-unsubstituted, meso-substituted porphyrin to form an osmate ester at the β,β'-position and reducing the osmate ester to form the title compound. The compounds are useful in photodynamic therapy (no data). Thus meso-tetraphenylporphyrin was osmylated and reduced with H2S to give the dihydroxy derivative in 49% yield.