Pub No:
107
Title:
99mTc-Glutathione: Role of Reducing Agent on Renal Retention
Authors:
Fritzberg, A.R., Lyster, D.M., and David Dolphin
Journal:
Int. J. Nucl. Med. Biol.
Year:
1978
Pages:
5, 87-92
Abstract:
The biodistribution of 99mTc-labeled glutathione in mice was dependent on the presence of Sn2+. The radioactivity ratio of the kidney to the liver increased from 1.17 to >6.0 as the Sn2+ ion concentration in the glutathione injection solution increased from 0 to 1.11 mM. The activity in the kidneys increased for the 1st 2 h and then decreased for 4 h. In the absence of the Sn2+, the radioactivity in the liver, kidney, and blood decreased 30 min after administration. Apparently, the reducing agent Sn2+ increases the retention of glutathione in the kidney.

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