Pub No:
236
Title:
Advances in Photochemotherapy
Authors:
Richter, A.M., Sternberg, E.D., Waterfield, E.M., David Dolphin, and Levy, J.G.
Journal:
Proc. SPIE - Int. Soc. Opt. Eng.,
Year:
1989
Pages:
Vol. 997, pp. 132-138
Abstract:
Benzoporphyrin derivative (BPD) synthesized from hematoporphyrin via protoporphyrin and involving the formation of Diels-Alder adducts, contains 4 components, i.e., mono and diacid derivatives of either ring A- or ring B-fused polymers. These compounds were isolated and tested for their photosensitizing activity in vitro in human and murine cells and in vivo in normal and tumor-bearing mice. All 4 forms of BPD showed potent photosensitization of cells in vitro with fluorescent light. In biodistribution studies in mice, BPD showed a similar distribution to DHE and was rapidly degraded in vivo. The diacid forms of BPD did not show appreciable skin photosensitization and the monoacid forms showed skin photosensitization at 3 h but not at 24 h. Photodynamic therapy of tumors in mice with BPD showed comparable results as that with Photofrin II.Benzoporphyrin derivative (BPD) synthesized from hematoporphyrin via protoporphyrin and involving the formation of Diels-Alder adducts, contains 4 components, i.e., mono and diacid derivatives of either ring A- or ring B-fused polymers. These compounds were isolated and tested for their photosensitizing activity in vitro in human and murine cells and in vivo in normal and tumor-bearing mice. All 4 forms of BPD showed potent photosensitization of cells in vitro with fluorescent light. In biodistribution studies in mice, BPD showed a similar distribution to DHE and was rapidly degraded in vivo. The diacid forms of BPD did not show appreciable skin photosensitization and the monoacid forms showed skin photosensitization at 3 h but not at 24 h. Photodynamic therapy of tumors in mice with BPD showed comparable results as that with Photofrin II.

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