Metalloporphyrins as Chemical Mimics of Cytochrome P-450 Systems
Chorghade, M.S., Hill, D.R., Lee, E.C., Pariza, R.J., David Dolphin, Hino, F., and Zhang, L.
Pure & Appl. Chem.
Certain synthetic metalloporphyrins, which have been shown to mimic cytochrome P 450 systems, were used to study the oxidative metabolism of several model drugs. Oxidation, hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation for a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites and provides a convenient methodology for their preparation.