Pub No:
311
Title:
Metalloporphyrins as Chemical Mimics of Cytochrome P-450 Systems
Authors:
Chorghade, M.S., Hill, D.R., Lee, E.C., Pariza, R.J., David Dolphin, Hino, F., and Zhang, L.
Journal:
Pure & Appl. Chem.
Year:
1996
Pages:
68(3), 753-756
Abstract:
Certain synthetic metalloporphyrins, which have been shown to mimic cytochrome P 450 systems, were used to study the oxidative metabolism of several model drugs. Oxidation, hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation for a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites and provides a convenient methodology for their preparation.

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