Application of Long-circulating Liposomes on Cancer Photodynamic Therapy
Saito, N., Oku, N., Hasegawa, Y., Okada, S., Tsukada, H., David Dolphin, and Namba, Y.
Progress in Drug Delivery System V
Photodynamic therapy (PDT) is useful in cancer treatment because of its low side effects. Since, the accumulation of photosensitizers into tumor tissues is quite low, attemps have been made to liposomalize them and investigated PDT by use of tumor-bearing mice. A porphyrin derivative, bcnzoporphyrin derivative monoacid ring A (BPD-MA) was incorporated into glucuronate modified liposomes, a kind of long-circulating liposomes, and was injected i.v. into Meth A sarcoma-bearing mice. Tumor regression and complete curing of tumor were observed after irradiation of laser light. These results suggest that long-circulating liposomal formulation of photo-sensitive agents is useful for PDT.