Oxaziridines as Possible Intermediates in Flavin Monooxygenases
Orf, H.W. and David Dolphin
Monooxygenases Proc. Natl. Acad. Sci. U.S.A.
The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed "carbonyl oxide" and flavin peroxide models are discussed.