99m Tc-Ethylthiomethylphosphonate: A New Renal Scanning Agent
Fritzberg, A.R., Lyster, D.M., and David Dolphin
Int. J. Nucl. Med. Biol.
The preparation and metabolism by mice and rabbits of 99mTc-labeled ethylthiomethyl-phosphonate (I) are presented. I was prepared by addition of 99mTcO4- to a solution of ethylthiomethylphosphonate, using either SnCl2.2H2O or formamidine sulfinic acid as reducing agents, and mixing; I was thus obtained at 95% purity. In both mice and rabbits, good kidney scans were obtained and rapid excretion occurred. Toxicity was also low.