Pub No:
94
Title:
On the Formation of Bile Pigments from Heme Proteins
Authors:
Hamilton, A.D. and David Dolphin
Journal:
Heterocycles
Year:
1977
Pages:
7, 817-829
Abstract:
It is proposed that the catabolism of heme to biliverdin involves an initial epoxidation of a protein-bound porphyrin at the exposed methine bridge. Rearrangement of the γ- to an α-epoxide followed by ring opening to a homooxaporphyrin would generate an electron-rich system capable of reacting with molecular oxygen to form a dioxetane. Fragmentation of the dioxetane to a mono formate ester of biliverdin followed by loss of CO would give the bile pigment.

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